MeSH Browser

MeSH Heading: Myosins
Tree Number(s): D05.750.078.730.475; D08.811.277.040.025.193.750; D12.776.210.500.600; D12.776.220.525.475
Unique ID: D009218
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009218
Annotation: general or unspecified; prefer specifics
Scope Note: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Entry Term(s): ATPase, Actin-Activated; ATPase, Actomyosin; ATPase, Myosin; Actin-Activated ATPase; Actomyosin ATPase; Actomyosin Adenosinetriphosphatase; Adenosine Triphosphatase, Myosin; Adenosinetriphosphatase, Actomyosin; Adenosinetriphosphatase, Myosin; Myosin; Myosin ATPase; Myosin Adenosinetriphosphatase
Registry Numbers: EC 3.6.4.1; EC 3.6.1.-
Related Numbers: EC 3.6.4.1
Previous Indexing: Adenosine Triphosphatase (1966-1968); Muscle Proteins (1966-1970)
Public MeSH Note: 2002; see MYOSIN 1973-2001, see MUSCLE PROTEINS 1969-1972; see ADENOSINE TRIPHOSPHATASE 1963-1968; for MYOSIN ATPASE see MYOSIN ATPASE 1993-2001, see ADENOSINE TRIPHOSPHATASE, MYOSIN 1989-1992, see ADENOSINE TRIPHOSPHATASE 1984-1988; for ADENOSINE TRIPHOSPHATASE, MYOSIN & MYOSIN ADENOSINETRIPHOSPHATASE see MYOSIN ATPASE 1993-2001; for ACTOMYOSIN ADENOSINETRIPHOSPHATASE & ADENOSINETRIPHOSPHATASE, ACTOMYOSIN see MYOSIN ATPASE 1993-2001, see ADENOSINE TRIPHOSPHATASE, MYOSIN 1989-92; for ACTOMYOSIN ATPASE see MYOSIN ATPASE 1993-2001, see ADENOSINE TRIPHOSPHATASE, MYOSIN 1989-1992, see ADENOSINE TRIPHOSPHATASE 1985-1988
History Note: 2002(1971); use ADENOSINE TRIPHOSPHATASE 1963-1968; for MYOSIN ATPASE use ADENOSINETRIPHOSPHATASE 1984-1988; for ACTOMYOSIN ATPASE use ADENOSINETRIPHOSPHATASE 1985-1988
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Polymers [D05.750]
  - Biopolymers [D05.750.078]
    - Microfilament Proteins [D05.750.078.730]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - Adenosine Triphosphatases [D08.811.277.040.025]
        
        Molecular Motor Proteins [D08.811.277.040.025.193]
        
        Dyneins [D08.811.277.040.025.193.249]
        
        Kinesins [D08.811.277.040.025.193.500]
        
        Myosins [D08.811.277.040.025.193.750]
        
        Myosin Heavy Chains [D08.811.277.040.025.193.750.249]
        
        Myosin Type I [D08.811.277.040.025.193.750.500]
        
        Myosin Type II [D08.811.277.040.025.193.750.750]
        
        Myosin Type III [D08.811.277.040.025.193.750.812]
        
        Myosin Type IV [D08.811.277.040.025.193.750.843]
        
        Myosin Type V [D08.811.277.040.025.193.750.875]
        
        Myosin VIIa [D08.811.277.040.025.193.750.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Contractile Proteins [D12.776.210]
    - Muscle Proteins [D12.776.210.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cytoskeletal Proteins [D12.776.220]
    - Microfilament Proteins [D12.776.220.525]

Myosins Preferred

Concept UI: M0014361
Registry Numbers: EC 3.6.4.1
Related Numbers: EC 3.6.4.1
Scope Note: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Terms: Myosins Preferred Term
Term UI T427508
Date10/30/2000
LexicalTag NON
ThesaurusID NLM (2002); Actin-Activated ATPase
Term UI T045269
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX); Adenosine Triphosphatase, Myosin
Term UI T045273
Date04/13/1992
LexicalTag NON
ThesaurusID NLM (1993); Adenosinetriphosphatase, Myosin
Term UI T045278
Date04/13/1992
LexicalTag NON
ThesaurusID NLM (1993); ATPase, Actin-Activated
Term UI T045270
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX); ATPase, Myosin
Term UI T045274
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX); Myosin
Term UI T027480
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1971); Myosin Adenosinetriphosphatase
Term UI T045279
Date04/13/1992
LexicalTag NON
ThesaurusID NLM (1993); Myosin ATPase
Term UI T045275
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989)

Actomyosin Adenosinetriphosphatase Related

Concept UI: M0375356
Registry Numbers: EC 3.6.1.-
Terms: Actomyosin Adenosinetriphosphatase Preferred Term
Term UI T045276
Date04/13/1992
LexicalTag NON
ThesaurusID NLM (1993); Actomyosin ATPase
Term UI T045271
Date04/15/1992
LexicalTag ACX
ThesaurusID NLM (1993); Adenosinetriphosphatase, Actomyosin
Term UI T045277
Date04/13/1992
LexicalTag NON
ThesaurusID NLM (1993); ATPase, Actomyosin
Term UI T045272
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX)

Myosins MeSH Descriptor Data 2024