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A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
2000; for INSULIN RECEPTOR PROTEIN-TYROSINE KINASE see INSULIN RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999; INSULIN-DEPENDENT PROTEIN TYROSINE KINASE was indexed under PROTEIN-TYROSINE KINASE 1986-1993 & PROTEIN KINASES 1983-1985
History Note
2000(1977); for INSULIN RECEPTOR PROTEIN-TYROSINE KINASE use RECEPTOR, INSULIN (NM) 1983-1993
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.