NLM Logo

Lafora Disease MeSH Descriptor Data 2023


MeSH Heading
Lafora Disease
Tree Number(s)
C10.228.140.490.375.130.650.500
C10.228.140.490.493.063.650.500
C10.574.500.529
C16.320.400.480
Unique ID
D020192
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020192
Scope Note
A form of stimulus sensitive MYOCLONIC EPILEPSY inherited as an autosomal recessive condition. The most common presenting feature is a single seizure in the second decade of life. This is followed by progressive myoclonus, myoclonic seizures, tonic-clonic seizures, focal occipital seizures, intellectual decline, and severe motor and coordination impairments. Most affected individuals do not live past the age of 25 years. Concentric amyloid (Lafora) bodies are found in neurons, liver, skin, bone, and muscle (From Menkes, Textbook of Childhood Neurology, 5th ed, pp111-110).
Entry Version
LAFORA DIS
Entry Term(s)
Epilepsy Progressive Myoclonic 2
Epilepsy, Progressive Myoclonic 2A
Epilepsy, Progressive Myoclonic, Lafora
Lafora Body Disease
Lafora Body Disease, Late Onset
Lafora Body Disorder
Lafora Progressive Myoclonic Epilepsy
Lafora Progressive Myoclonus Epilepsy
Lafora Type Progressive Myoclonic Epilepsy
Lafora-Body Disease, Late Onset
Late Onset Lafora Body Disease
Myoclonic Epilepsy of Lafora
Progressive Myoclonic Epilepsy Type 2
Progressive Myoclonic Epilepsy, Lafora
Progressive Myoclonic Epilepsy, Lafora Type
Progressive Myoclonus Epilepsy, Lafora Type
Previous Indexing
Epilepsies, Myoclonic (1977-1999)
Epilepsy (1966-1976)
Public MeSH Note
2000; see Epilepsy, Myoclonic 1977-1999
History Note
2000; use Epilepsy, Myoclonic 1977-1999
Date Established
2000/01/01
Date of Entry
1999/11/03
Revision Date
2017/02/24
Lafora Disease Preferred
Lafora Body Disease, Late Onset Narrower
page delivered in 0.194s