MeSH Browser

MeSH Heading: Pantothenate Kinase-Associated Neurodegeneration
Tree Number(s): C10.228.140.079.800; C10.228.140.744.320; C10.228.662.575; C10.574.500.700; C16.320.400.650
Unique ID: D006211
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006211
Scope Note: A rare autosomal recessive degenerative disorder which usually presents in late childhood or adolescence. Clinical manifestations include progressive MUSCLE SPASTICITY; hyperreflexia; MUSCLE RIGIDITY; DYSTONIA; DYSARTHRIA; and intellectual deterioration which progresses to severe dementia over several years. (From Adams et al., Principles of Neurology, 6th ed, p972; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp972-929)
Entry Term(s): Hallervorden-Spatz Disease; Hallervorden-Spatz Syndrome; Neuroaxonal Dystrophy, Juvenile-Onset; Neurodegeneration With Brain Iron Accumulation 1; Neurodegeneration with Brain Iron Accumulation Type 1; PKAN Neuroaxonal Dystrophy, Juvenile-Onset; Pigmentary Pallidal Atrophy; Pigmentary Pallidal Degeneration
Public MeSH Note: 2008; see HALLERVORDEN-SPATZ SYNDROME 1991-2007, see BASAL GANGLIA DISEASES 1979-1990, see BRAIN DISEASES 1975-1978
History Note: 2008 (1965)
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08

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Pantothenate Kinase-Associated Neurodegeneration MeSH Descriptor Data 2024