MeSH Browser

MeSH Heading: Alexander Disease
Tree Number(s): C10.228.140.163.100.362.312; C10.228.140.695.625.312; C10.314.400.312; C10.574.500.024; C16.320.400.024; C16.320.565.189.362.312; C18.452.132.100.362.312; C18.452.648.189.362.312
Unique ID: D038261
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038261
Scope Note: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
Entry Term(s): Alexander's Disease; Demyelinogenic Leukodystrophy; Dysmyelinogenic Leukodystrophy; Fibrinoid Degeneration of Astrocytes; Leukodystrophy with Rosenthal Fibers
See Also: Glial Fibrillary Acidic Protein
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0415670
Scope Note: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
Terms: Alexander Disease Preferred Term
Term UI T483481
Date02/26/2002
LexicalTag EPO
ThesaurusID; Alexander's Disease
Term UI T483482
Date02/26/2002
LexicalTag EPO
ThesaurusID NLM (2003); Demyelinogenic Leukodystrophy
Term UI T840850
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Dysmyelinogenic Leukodystrophy
Term UI T840851
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Fibrinoid Degeneration of Astrocytes
Term UI T840852
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Leukodystrophy with Rosenthal Fibers
Term UI T840853
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

Alexander Disease MeSH Descriptor Data 2024