Because of a lapse in government funding, the information on this
website may not be up to date, transactions submitted via the
website may not be processed, and the agency may not be able to
respond to inquiries until appropriations are enacted. The NIH
Clinical Center (the research hospital of NIH) is open. For more
details about its operating status, please visit
cc.nih.gov. Updates
regarding government operating status and resumption of normal
operations can be found at
opm.gov.
Muscular Dystrophy, Duchenne MeSH Descriptor Data 2025
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
Entry Term(s)
Becker Muscular Dystrophy
Becker's Muscular Dystrophy
Cardiomyopathy, Dilated, 3B
Cardiomyopathy, Dilated, X-Linked
Childhood Muscular Dystrophy, Pseudohypertrophic
Childhood Pseudohypertrophic Muscular Dystrophy
Duchenne Muscular Dystrophy
Duchenne and Becker Muscular Dystrophy
Duchenne-Becker Muscular Dystrophy
Duchenne-Type Progressive Muscular Dystrophy
Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type
Muscular Dystrophy, Becker
Muscular Dystrophy, Becker Type
Muscular Dystrophy, Childhood, Pseudohypertrophic
Muscular Dystrophy, Duchenne Type
Muscular Dystrophy, Duchenne and Becker Types
Muscular Dystrophy, Pseudohypertrophic
Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type
Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)