MeSH Browser

MeSH Heading: TRPP Cation Channels
Tree Number(s): D12.776.157.530.400.150.900; D12.776.157.530.400.901.777; D12.776.543.585.400.150.900; D12.776.543.585.400.901.777
Unique ID: D050396
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050396
Scope Note: A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES. Polycystin-1 and Polycystin-2 form a heteromeric channel essential for regulation of CILIUM length and fluid-flow mechanosensation by the primary cilium in renal epithelium. Polycystin-2 can also function as a homotetramer and modulates calcium ion release from stimulated RYANODINE RECEPTORS in CARDIOMYOCYTES.
Entry Term(s): Autosomal Dominant Polycystic Kidney Disease Type II Protein; PKD1 Protein; PKD2 Protein; Polycystic Breakpoint (PBP) Protein; Polycystic Kidney Disease 1 Protein; Polycystic Kidney Disease 2 Protein; Polycystin; Polycystin 1; Polycystin 2; Polycystins
Registry Numbers: 0
Previous Indexing: Polycystic Kidney Diseases (1995-2005)
Public MeSH Note: 2026; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN was indexed under TRPP CATION CHANNELS 2006-2025, and under PROTEINS 1994-2006; POLYCYSTIC KIDNEY DISEASE 2 PROTEIN was indexed under TRPP CATION CHANNELS 2006-2025, and under MEMBRANE PROTEINS 1996-2006
History Note: 2026 (2006)
Date Introduced: 2006/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0474795
Registry Numbers: 0
Scope Note: A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES. Polycystin-1 and Polycystin-2 form a heteromeric channel essential for regulation of CILIUM length and fluid-flow mechanosensation by the primary cilium in renal epithelium. Polycystin-2 can also function as a homotetramer and modulates calcium ion release from stimulated RYANODINE RECEPTORS in CARDIOMYOCYTES.
Terms: TRPP Cation Channels Preferred Term
Term UI T616083
Date10/28/2004
LexicalTag NON
ThesaurusID NLM (2006); Polycystin
Term UI T001007247
Date02/10/2020
LexicalTag NON
ThesaurusID NLM (2021); Polycystins
Term UI T616084
Date10/28/2004
LexicalTag NON
ThesaurusID NLM (2006)

Concept UI: M0232666
Registry Numbers: 0
Terms: Polycystic Kidney Disease 1 Protein Preferred Term
Term UI T001147423
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (1994); PKD1 Protein
Term UI T001147424
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (1994); Polycystic Breakpoint (PBP) Protein
Term UI T001147425
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (1994); Polycystin 1
Term UI T001147426
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (1994)

Concept UI: M0261687
Registry Numbers: 0
Terms: Polycystic Kidney Disease 2 Protein Preferred Term
Term UI T001147427
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (1996); Autosomal Dominant Polycystic Kidney Disease Type II Protein
Term UI T001147428
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (2006); PKD2 Protein
Term UI T001147430
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (2026); Polycystin 2
Term UI T001147429
Date03/17/2025
LexicalTag NON
ThesaurusID NLM (1996)

TRPP Cation Channels MeSH Descriptor Data 2026