MeSH Browser

MeSH Heading: ADAM Proteins
Tree Number(s): D08.811.277.656.675.374.102; D09.400.430.500; D12.776.395.033
Unique ID: D051722
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051722
Scope Note: A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.
Entry Term(s): A Disintegrin and Metalloprotease Protein; A Disintegrin and Metalloprotease Proteins; ADAM (A Disintegrin and Metalloprotease) Proteins
Registry Numbers: EC 3.4.24.-
Public MeSH Note: 2006
History Note: 2006
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Metalloproteases [D08.811.277.656.675]
        
        Metalloendopeptidases [D08.811.277.656.675.374]
        
        ADAM Proteins [D08.811.277.656.675.374.102]
        
        ADAM12 Protein [D08.811.277.656.675.374.102.125]
        
        ADAM10 Protein [D08.811.277.656.675.374.102.250]
        
        ADAM17 Protein [D08.811.277.656.675.374.102.375]
        
        ADAMTS Proteins [D08.811.277.656.675.374.102.500]
        
        Fertilins [D08.811.277.656.675.374.102.750]
        
        Botulinum Toxins [D08.811.277.656.675.374.153]
        
        Collagenases [D08.811.277.656.675.374.205]
        
        Endothelin-Converting Enzymes [D08.811.277.656.675.374.229]
        
        Gelatinases [D08.811.277.656.675.374.252]
        
        Insulysin [D08.811.277.656.675.374.300]
        
        Lysostaphin [D08.811.277.656.675.374.452]
        
        Matrix Metalloproteinases [D08.811.277.656.675.374.525]
        
        Mitochondrial Processing Peptidase [D08.811.277.656.675.374.563]
        
        Neprilysin [D08.811.277.656.675.374.600]
        
        PHEX Phosphate Regulating Neutral Endopeptidase [D08.811.277.656.675.374.616]
        
        Pregnancy-Associated Plasma Protein-A [D08.811.277.656.675.374.632]
        
        Procollagen N-Endopeptidase [D08.811.277.656.675.374.664]
        
        Pronase [D08.811.277.656.675.374.680]
        
        Thermolysin [D08.811.277.656.675.374.827]

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]

ADAM Proteins Preferred

Concept UI: M0481642
Registry Numbers: EC 3.4.24.-
Scope Note: A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.
Terms: ADAM Proteins Preferred Term
Term UI T632604
Date03/07/2005
LexicalTag ACX
ThesaurusID NLM (2006); A Disintegrin and Metalloprotease Proteins
Term UI T632603
Date03/07/2005
LexicalTag NON
ThesaurusID NLM (2006); ADAM (A Disintegrin and Metalloprotease) Proteins
Term UI T632602
Date03/07/2005
LexicalTag ACX
ThesaurusID NLM (2006); A Disintegrin and Metalloprotease Protein
Term UI T001085045
Date07/20/2020
LexicalTag NON
ThesaurusID NLM (2022)

ADAM Proteins MeSH Descriptor Data 2024