MeSH Browser

MeSH Heading: Cytochrome P-450 CYP11B2
Tree Number(s): D08.244.453.484.500; D08.244.453.915.050; D08.811.682.690.708.170.425.500; D08.811.682.690.708.170.915.050; D12.776.422.220.453.484.500; D12.776.422.220.453.915.050
Unique ID: D019405
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019405
Annotation: /antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Entry Term(s): Aldosterone Synthase; Aldosterone Synthase Cytochrome P-450; Aldosynthase; CYP 11B2; CYP11B2; Corticosterone 18-hydroxylase; Corticosterone 18-monooxygenase; Cytochrome P-450c11AS; Cytochrome P450 11B2; Cytochrome P450Aldo; P450c11AS; Steroid 18-Hydroxylase
Related Numbers: 37256-75-0; EC 1.14.15.4
Previous Indexing: Cytochrome P-450 (1984-1996); Desoxycorticosterone (1979-1982); Steroid 11 beta-Monooxygenase (1994-1996); Steroid Hydroxylases (1979-1993)
Public MeSH Note: 2015; see ALDOSTERONE SYNTHASE 2003-2014; see CYTOCHROME P-450 CYP11B2 1977-2002; for STEROID 18-HYDROXYLASE see CYTOCHROME P-450 1984-1996, see STEROID 11-HYDROXYLASE 1994-1996, see STEROID HYDROXYLASES 1979-1993, & see DESOXYCORTICOSTERONE 1979-1982
History Note: 2015 (1979)
Date Established: 1997/01/01
Date of Entry: 1996/06/24
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 11 [D08.244.453.484]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 11 [D08.811.682.690.708.170.425]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.425.250]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.425.500]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.425.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 11 [D12.776.422.220.453.484]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.484.250]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.484.500]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.484.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Cytochrome P-450 CYP11B2 Preferred

Concept UI: M0028872
Related Numbers: 37256-75-0; EC 1.14.15.4
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Terms: Cytochrome P-450 CYP11B2 Preferred Term
Term UI T057860
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1997); CYP11B2
Term UI T057862
Date02/22/1996
LexicalTag ABB
ThesaurusID NLM (1997); P450c11AS
Term UI T057863
Date03/14/1996
LexicalTag NON
ThesaurusID NLM (1997); Steroid 18-Hydroxylase
Term UI T057852
Date02/22/1996
LexicalTag NON
ThesaurusID NLM (1997); Aldosterone Synthase
Term UI T057853
Date02/22/1996
LexicalTag NON
ThesaurusID NLM (1997); Aldosterone Synthase Cytochrome P-450
Term UI T057854
Date02/22/1996
LexicalTag NON
ThesaurusID NLM (1997); Aldosynthase
Term UI T057855
Date02/22/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P450Aldo
Term UI T057856
Date02/22/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP 11B2
Term UI T057857
Date02/22/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P450 11B2
Term UI T057858
Date03/10/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P-450c11AS
Term UI T057861
Date03/14/1996
LexicalTag NON
ThesaurusID NLM (1997)

Corticosterone 18-monooxygenase Related

Cytochrome P-450 CYP11B2 MeSH Descriptor Data 2024