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An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Entry Term(s)
CYP51 Cytochrome P-450
Cytochrome P-450 CYP51
Eburicol 14 alpha-Demethylase
Eburicol 14alpha-Demethylase
Lanosterol 14 alpha-Demethylase
Obtusifoliol 14alpha-Demethylase
Sterol 14-Demethylases
Sterol 14-alpha-Demethylase
Registry Numbers
EC 1.14.14.154
Public MeSH Note
2011; STEROL 14-DEMETHYLASE was indexed under CYTOCHROME P-450 ENZYME SYSTEM 2009-2010, under OXIDOREDUCTASES 1978-2008, & under LANOSTEROL 1976-1982
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.