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Steroid 11-beta-Hydroxylase MeSH Descriptor Data 2023


MeSH Heading
Steroid 11-beta-Hydroxylase
Tree Number(s)
D08.244.453.484.750
D08.244.453.915.750
D08.811.682.690.708.170.425.750
D08.811.682.690.708.170.915.750
D12.776.422.220.453.484.750
D12.776.422.220.453.915.750
Unique ID
D013252
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013252
Scope Note
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Entry Term(s)
11 beta-Hydroxylase
CYP 11B1
CYP11B1
Cytochrome P-450 CYP11B1
Cytochrome P-450(11 beta)
Cytochrome P450 11B1
Steroid 11 Hydroxylase
Steroid 11-Hydroxylase
Steroid 11-beta-Monooxygenase
Steroid-11-Hydroxylase
Registry Number
EC 1.14.15.4
CAS Type 1 Name
Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating)
Previous Indexing
Steroid Hydroxylases (1973-1977)
See Also
Adrenal Hyperplasia, Congenital
Public MeSH Note
2003; see STEROID 11 BETA-MONOOXYGENASE 1997-2002, see STEROID 11-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990, see STEROID-11-HYDROXYLASE 1978-1989
History Note
2003 (1978)
Entry Combination
deficiency:Adrenal Hyperplasia, Congenital
Date Established
1991/01/01
Date of Entry
1977/04/15
Revision Date
2016/05/27
Steroid 11-beta-Hydroxylase Preferred
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