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Steroid 17-alpha-Hydroxylase MeSH Descriptor Data 2024


MeSH Heading
Steroid 17-alpha-Hydroxylase
Tree Number(s)
D08.244.453.487.500
D08.244.453.915.748
D08.811.682.690.708.170.444.500
D08.811.682.690.708.170.915.748
D12.776.422.220.453.487.500
D12.776.422.220.453.915.748
Unique ID
D013254
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D013254
Scope Note
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Entry Term(s)
17 alpha-Hydroxylase
17 alpha-Hydroxylase Cytochrome P-450
17 alpha-Hydroxyprogesterone Aldolase
17,20-Desmolase
17,20-Lyase
CYP17
Cytochrome P-450(17 alpha)
Cytochrome P-450(17-alpha)
Cytochrome P450(17 alpha)
Hydroxyprogesterone Aldolase
P450(c17)
Steroid 17 alpha-Hydroxylase
Steroid 17 alpha-Monooxygenase
Steroid 17-Hydroxylase
Steroid 17-Monooxygenase
Steroid-17-Hydroxylase
Related Numbers
62213-24-5
9029-67-8
CAS Type 1 Name
Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
Previous Indexing
Steroid Hydroxylases (1973-1977)
See Also
Adrenal Hyperplasia, Congenital
Public MeSH Note
2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997
History Note
2003 (1978)
Entry Combination
deficiency:Adrenal Hyperplasia, Congenital
Date Established
1991/01/01
Date of Entry
1977/04/15
Revision Date
2016/06/01
Steroid 17-alpha-Hydroxylase Preferred
17 alpha-Hydroxyprogesterone Aldolase Narrower
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