MeSH Browser

MeSH Heading: Steroid 12-alpha-Hydroxylase
Tree Number(s): D08.244.453.900.500; D08.244.453.915.730; D08.811.682.690.708.170.900.500; D08.811.682.690.708.170.915.730; D12.776.422.220.453.900.500; D12.776.422.220.453.915.730
Unique ID: D013253
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013253
Scope Note: A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Entry Term(s): 12-alpha-Hydroxylase; 12alpha-Hydroxylase; CYP8B1; Cytochrome P450 8B1; Cytochrome P450 CYP8B1; Steroid 12-Hydroxylase; Steroid 12-Monooxygenase; Steroid-12-Hydroxylase; Steroid-12-Monooxygenase; Sterol 12 alpha-Hydroxylase; Sterol 12-alpha-Hydroxylase
Registry Number: EC 1.14.18.8
CAS Type 1 Name: Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
Public MeSH Note: 2003; see STEROID 12-MONOOXYGENASE 1997-2002, see STEROID 12-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 12-MONOOXYGENASE see STEROID 12-HYDROXYLASE 1978-1996
History Note: 2003 (1978)
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 8 [D08.244.453.900]
      - Steroid 12-alpha-Hydroxylase [D08.244.453.900.500]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 8 [D08.811.682.690.708.170.900]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.900.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 8 [D12.776.422.220.453.900]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.900.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Steroid 12-alpha-Hydroxylase Preferred

Concept UI: M0020522
Registry Number: EC 1.14.18.8
Scope Note: A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Terms: Steroid 12-alpha-Hydroxylase Preferred Term
Term UI T038944
Date09/19/1984
LexicalTag NON
ThesaurusID UNK (19XX); Steroid 12-Monooxygenase
Term UI T038946
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Steroid 12-Hydroxylase
Term UI T038949
Date04/24/1996
LexicalTag NON
ThesaurusID NLM (1997); Steroid-12-Hydroxylase
Term UI T038948
Date05/01/1990
LexicalTag NON
ThesaurusID NLM (1991); CYP8B1
Term UI T487146
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); Sterol 12 alpha-Hydroxylase
Term UI T333314
LexicalTag NON
ThesaurusID NLM (2005); Sterol 12-alpha-Hydroxylase
Term UI T487140
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); 12-alpha-Hydroxylase
Term UI T487141
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); 12alpha-Hydroxylase
Term UI T487142
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); Cytochrome P450 8B1
Term UI T487145
Date03/25/2002
LexicalTag NON
ThesaurusID NLM (2003); Steroid-12-Monooxygenase
Term UI T038945
Date09/01/1989
LexicalTag NON
ThesaurusID NLM (1990); Cytochrome P450 CYP8B1
Term UI T333313
LexicalTag NON
ThesaurusID NLM (2005)

Steroid 12-alpha-Hydroxylase MeSH Descriptor Data 2024