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25-Hydroxyvitamin D3 1-alpha-Hydroxylase MeSH Descriptor Data 2025
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002
History Note
2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).