MeSH Browser

MeSH Heading: Aromatase
Tree Number(s): D08.244.453.489.500; D08.244.453.915.099; D08.811.682.690.708.170.447.500; D08.811.682.690.708.170.915.099; D12.776.422.220.453.489.500; D12.776.422.220.453.915.099
Unique ID: D001141
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001141
Scope Note: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Entry Term(s): Androstenedione Aromatase; CYP 19; CYP19; CYP19 Protein; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Estrogen Synthase; Estrogen Synthetase; P450AROM
Registry Number: EC 1.14.14.1
Previous Indexing: Androstanes (1972-1974); Estrogens (1972-1974); Oxidoreductases (1972-1974)
Public MeSH Note: 86; was see under OXIDOREDUCTASES 1975-85
History Note: 86(75); was see under OXIDOREDUCTASES 1975-85
Entry Combination: antagonists & inhibitors:Aromatase Inhibitors
Date Established: 1986/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/27

Entry Combination: antagonists & inhibitors:Aromatase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 19 [D08.244.453.489]
      - Aromatase [D08.244.453.489.500]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 19 [D08.811.682.690.708.170.447]
        
        Aromatase [D08.811.682.690.708.170.447.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 19 [D12.776.422.220.453.489]
        
        Aromatase [D12.776.422.220.453.489.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Aromatase Preferred

Concept UI: M0001707
Registry Number: EC 1.14.14.1
Scope Note: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Terms: Aromatase Preferred Term
Term UI T003429
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Estrogen Synthetase
Term UI T003430
Date11/20/1980
LexicalTag NON
ThesaurusID UNK (19XX); Estrogen Synthase
Term UI T003431
Date02/08/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P450 19
Term UI T003432
Date02/23/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP19 Protein
Term UI T485480
Date03/13/2002
LexicalTag NON
ThesaurusID NLM (2003); Cytochrome P-450(AROM)
Term UI T003434
Date05/07/1987
LexicalTag NON
ThesaurusID UNK (19XX); CYP 19
Term UI T003435
Date02/21/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P-450 CYP19
Term UI T003436
Date02/21/1996
LexicalTag NON
ThesaurusID NLM (1997); P450AROM
Term UI T003437
Date04/24/1996
LexicalTag ABB
ThesaurusID NLM (1997); Androstenedione Aromatase
Term UI T003428
Date10/07/1986
LexicalTag NON
ThesaurusID UNK (19XX); CYP19
Term UI T003433
Date02/21/1996
LexicalTag ABB
ThesaurusID NLM (1997)

Aromatase MeSH Descriptor Data 2024