MeSH Browser

MeSH Heading: Cholesterol 7-alpha-Hydroxylase
Tree Number(s): D08.244.453.890.500; D08.244.453.915.200; D08.811.682.690.708.170.890.500; D08.811.682.690.708.170.915.200; D12.776.422.220.453.890.500; D12.776.422.220.453.915.200
Unique ID: D002790
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002790
Scope Note: A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Entry Term(s): CYP 7; CYP 7A; CYP7; CYP7A; Cholesterol 7-alpha-Monooxygenase; Cholesterol 7alpha-Hydroxylase; Cholesterol-7-Hydroxylase; Cytochrome P-450 CYP7; Cytochrome P450 7
Registry Numbers: EC 1.14.14.23
Related Numbers: 9037-53-0
CAS Type 1 Name: Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating)
NLM Classification #: QU 140
Previous Indexing: Cholesterol (1974); Steroid Hydroxylases (1974)
Public MeSH Note: 2003; see CHOLESTEROL 7 ALPHA-MONOOXYGENASE 1997-2002, see CHOLESTEROL-7-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1975-1990
History Note: 2003 (1975)
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/06/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 7 [D08.244.453.890]
      - Cholesterol 7-alpha-Hydroxylase [D08.244.453.890.500]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 7 [D08.811.682.690.708.170.890]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.890.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 7 [D12.776.422.220.453.890]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.890.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Cholesterol 7-alpha-Hydroxylase Preferred

Concept UI: M0004276
Registry Numbers: EC 1.14.14.23
Related Numbers: 9037-53-0
Scope Note: A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Terms: Cholesterol 7-alpha-Hydroxylase Preferred Term
Term UI T008111
Date03/10/1996
LexicalTag NON
ThesaurusID NLM (1997); Cholesterol 7alpha-Hydroxylase
Term UI T008108
Date12/18/1981
LexicalTag NON
ThesaurusID UNK (19XX); Cholesterol-7-Hydroxylase
Term UI T008109
Date02/21/1996
LexicalTag NON
ThesaurusID NLM (1997); Cytochrome P-450 CYP7
Term UI T008110
Date03/10/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP 7
Term UI T008112
Date03/10/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P450 7
Term UI T008113
Date03/10/1996
LexicalTag NON
ThesaurusID NLM (1997); CYP7
Term UI T008114
Date03/10/1996
LexicalTag ABB
ThesaurusID NLM (1997); CYP 7A
Term UI T008115
Date12/24/1997
LexicalTag ABB
ThesaurusID NLM (1999); Cholesterol 7-alpha-Monooxygenase
Term UI T008107
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); CYP7A
Term UI T008116
Date10/31/1997
LexicalTag ABB
ThesaurusID NLM (1999)

Cholesterol 7-alpha-Hydroxylase MeSH Descriptor Data 2024