MeSH Browser

MeSH Heading: Steroid 11-beta-Hydroxylase
Tree Number(s): D08.244.453.484.750; D08.244.453.915.750; D08.811.682.690.708.170.425.750; D08.811.682.690.708.170.915.750; D12.776.422.220.453.484.750; D12.776.422.220.453.915.750
Unique ID: D013252
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013252
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Entry Term(s): 11 beta-Hydroxylase; CYP 11B1; CYP11B1; Cytochrome P-450 CYP11B1; Cytochrome P-450(11 beta); Cytochrome P450 11B1; Steroid 11 Hydroxylase; Steroid 11-Hydroxylase; Steroid 11-beta-Monooxygenase; Steroid-11-Hydroxylase
CAS Type 1 Name: Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
See Also: Adrenal Hyperplasia, Congenital
Public MeSH Note: 2003; see STEROID 11 BETA-MONOOXYGENASE 1997-2002, see STEROID 11-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990, see STEROID-11-HYDROXYLASE 1978-1989
History Note: 2003 (1978)
Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/05/27

Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 11 [D08.244.453.484]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 11 [D08.811.682.690.708.170.425]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.425.250]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.425.500]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.425.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 11 [D12.776.422.220.453.484]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.484.250]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.484.500]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.484.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Steroid 11-beta-Hydroxylase Preferred

Concept UI: M0020521
Scope Note: A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Terms: Steroid 11-beta-Hydroxylase Preferred Term
Term UI T038935
Date06/29/1983
LexicalTag NON
ThesaurusID UNK (19XX); Cytochrome P-450(11 beta)
Term UI T038934
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); Steroid 11 Hydroxylase
Term UI T038936
Date01/26/1978
LexicalTag NON
ThesaurusID UNK (19XX); Steroid-11-Hydroxylase
Term UI T038937
Date11/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Steroid 11-Hydroxylase
Term UI T038938
Date03/29/1977
LexicalTag NON
ThesaurusID UNK (19XX); CYP11B1
Term UI T038939
Date02/21/1996
LexicalTag ABB
ThesaurusID NLM (1997); Steroid 11-beta-Monooxygenase
Term UI T038940
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); CYP 11B1
Term UI T038941
Date02/21/1996
LexicalTag ABB
ThesaurusID NLM (1997); Cytochrome P450 11B1
Term UI T038942
Date02/23/1996
LexicalTag NON
ThesaurusID NLM (1997); 11 beta-Hydroxylase
Term UI T038933
Date06/29/1983
LexicalTag NON
ThesaurusID UNK (19XX); Cytochrome P-450 CYP11B1
Term UI T038943
Date03/01/1996
LexicalTag NON
ThesaurusID NLM (1997)

Steroid 11-beta-Hydroxylase MeSH Descriptor Data 2024