MeSH Browser

MeSH Heading: Mechanistic Target of Rapamycin Complex 2
Tree Number(s): D05.500.356; D08.811.913.696.620.682.700.931.750; D12.776.476.563.931.750
Unique ID: D000076225
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076225
Scope Note: A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.
Entry Term(s): MTORC-2; TOR Complex 2; TORC2; Target of Rapamycin Complex 2; mTORC2
Public MeSH Note: 2018; see TOR COMPLEX 2 2013-2017; MECHANISTIC TARGET OF RAPAMYCIN 2 COMPLEX was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017
History Note: 2018 (2013)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0579319
Scope Note: A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.
Terms: Mechanistic Target of Rapamycin Complex 2 Preferred Term
Term UI T000925756
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2018); TOR Complex 2
Term UI T000925755
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2013); Target of Rapamycin Complex 2
Term UI T000925757
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2018); MTORC-2
Term UI T000925787
Date05/31/2017
LexicalTag ABB
ThesaurusID NLM (2018); mTORC2
Term UI T833714
Date12/03/2012
LexicalTag ABB
ThesaurusID NLM (2013); TORC2
Term UI T833716
Date12/03/2012
LexicalTag ABB
ThesaurusID NLM (2013)

Mechanistic Target of Rapamycin Complex 2 MeSH Descriptor Data 2024