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Mechanistic Target of Rapamycin Complex 2 MeSH Descriptor Data 2025


MeSH Heading
Mechanistic Target of Rapamycin Complex 2
Tree Number(s)
D05.500.356
D08.811.913.696.620.682.700.931.750
D12.776.476.563.931.750
Unique ID
D000076225
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076225
Scope Note
A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.
Entry Term(s)
MTORC-2
TOR Complex 2
TORC2
Target of Rapamycin Complex 2
mTORC2
Registry Numbers
EC 2.7.11.1
Public MeSH Note
2018; see TOR COMPLEX 2 2013-2017; MECHANISTIC TARGET OF RAPAMYCIN 2 COMPLEX was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017
History Note
2018 (2013)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/05/21
Mechanistic Target of Rapamycin Complex 2 Preferred
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