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A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Entry Term(s)
Caspase 2 Subunit p12
Caspase 2 Subunit p13
Caspase 2 Subunit p18
Caspase-2
ICH-1 Protease
Pro-Caspase-2
Procaspase-2
Registry Numbers
EC 3.4.22.-
0
EC 3.4.22.-
EC 3.4.22.-
EC 3.4.22.-
Public MeSH Note
2007; CASPASE 2 was indexed under CASPASES 1994-2006
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.