MeSH Browser

MeSH Heading: Kininogens
Tree Number(s): D12.644.276.812.654; D12.776.124.125.635; D12.776.467.812.654; D12.776.811.420; D23.119.630; D23.469.050.375.425; D23.529.812.654
Unique ID: D007704
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007704
Annotation: cysteine proteinase inhib; /‌drug eff /‌physiol permitted
Scope Note: Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Entry Term(s): Cystatins, Kininogen; Kininogen; Prekinins; Prokinins; T-Kininogen; Thiostatin
Pharm Action: Cysteine Proteinase Inhibitors
Previous Indexing: Kinins (1966-1971); Proteins (1966-1971)
Public MeSH Note: 74
History Note: 74(72)
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0012050
Scope Note: Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Terms: Kininogens Preferred Term
Term UI T023125
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1972); Cystatins, Kininogen
Term UI T023124
Date05/25/1989
LexicalTag NON
ThesaurusID NLM (1990); Prekinins
Term UI T023126
Date04/24/1989
LexicalTag NON
ThesaurusID NLM (1990); Prokinins
Term UI T023127
Date04/24/1989
LexicalTag NON
ThesaurusID NLM (1990)

Kininogens MeSH Descriptor Data 2024