MeSH Browser

MeSH Heading: Agouti Signaling Protein
Tree Number(s): D12.644.276.049; D12.776.467.049; D23.529.049
Unique ID: D054366
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054366
Scope Note: A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Entry Term(s): ASIP Protein; Agouti Protein; Agouti Switch Protein
Registry Numbers: 0
Previous Indexing: Intercellular Signaling Peptides and Proteins (1994-2007)
Public MeSH Note: 2008; AGOUTI PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 1993-2007
History Note: 2008 (1993)
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0214413
Registry Numbers: 0
Scope Note: A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Terms: Agouti Signaling Protein Preferred Term
Term UI T414831
Date05/19/2000
LexicalTag NON
ThesaurusID NLM (2008); Agouti Protein
Term UI T244418
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Agouti Switch Protein
Term UI T687021
Date12/01/2006
LexicalTag NON
ThesaurusID NLM (2008); ASIP Protein
Term UI T687022
Date12/01/2006
LexicalTag NON
ThesaurusID NLM (2008)

Agouti Signaling Protein MeSH Descriptor Data 2024