MeSH Browser

MeSH Heading: Sterol 14-Demethylase
Tree Number(s): D08.244.453.878.500; D08.244.453.915.880; D08.811.682.690.708.170.499.500; D08.811.682.690.708.170.915.880; D12.776.422.220.453.878.500; D12.776.422.220.453.915.880
Unique ID: D058886
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D058886
Scope Note: An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Entry Term(s): CYP51 Cytochrome P-450; Cytochrome P-450 CYP51; Eburicol 14 alpha-Demethylase; Eburicol 14alpha-Demethylase; Lanosterol 14 alpha-Demethylase; Obtusifoliol 14alpha-Demethylase; Sterol 14-Demethylases; Sterol 14-alpha-Demethylase
Registry Number: EC 1.14.14.154
Public MeSH Note: 2011; STEROL 14-DEMETHYLASE was indexed under CYTOCHROME P-450 ENZYME SYSTEM 2009-2010, under OXIDOREDUCTASES 1978-2008, & under LANOSTEROL 1976-1982
History Note: 2011
Entry Combination: antagonists & inhibitors:14-alpha Demethylase Inhibitors
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Revision Date: 2019/07/05

Entry Combination: antagonists & inhibitors:14-alpha Demethylase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Cytochrome P450 Family 51 [D08.244.453.878]
      - Sterol 14-Demethylase [D08.244.453.878.500]

Enzymes and Coenzymes [D08]
- Cytochromes [D08.244]
  - Cytochrome P-450 Enzyme System [D08.244.453]
    - Steroid Hydroxylases [D08.244.453.915]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Cytochrome P450 Family 51 [D08.811.682.690.708.170.499]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.499.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxygenases [D08.811.682.690]
      - Mixed Function Oxygenases [D08.811.682.690.708]
        
        Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
        
        Steroid Hydroxylases [D08.811.682.690.708.170.915]
        
        Cholesterol 24-Hydroxylase [D08.811.682.690.708.170.915.025]
        
        Cytochrome P-450 CYP11B2 [D08.811.682.690.708.170.915.050]
        
        Aromatase [D08.811.682.690.708.170.915.099]
        
        Cholestanetriol 26-Monooxygenase [D08.811.682.690.708.170.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D08.811.682.690.708.170.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D08.811.682.690.708.170.915.400]
        
        Steroid 12-alpha-Hydroxylase [D08.811.682.690.708.170.915.730]
        
        Steroid 16-alpha-Hydroxylase [D08.811.682.690.708.170.915.737]
        
        Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
        
        Steroid 11-beta-Hydroxylase [D08.811.682.690.708.170.915.750]
        
        Steroid 21-Hydroxylase [D08.811.682.690.708.170.915.760]
        
        Sterol 14-Demethylase [D08.811.682.690.708.170.915.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Cytochrome P450 Family 51 [D12.776.422.220.453.878]
        
        Sterol 14-Demethylase [D12.776.422.220.453.878.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Hemeproteins [D12.776.422]
    - Cytochromes [D12.776.422.220]
      - Cytochrome P-450 Enzyme System [D12.776.422.220.453]
        
        Steroid Hydroxylases [D12.776.422.220.453.915]
        
        Cholesterol 24-Hydroxylase [D12.776.422.220.453.915.025]
        
        Cytochrome P-450 CYP11B2 [D12.776.422.220.453.915.050]
        
        Aromatase [D12.776.422.220.453.915.099]
        
        Cholestanetriol 26-Monooxygenase [D12.776.422.220.453.915.150]
        
        Cholesterol 7-alpha-Hydroxylase [D12.776.422.220.453.915.200]
        
        Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]
        
        25-Hydroxyvitamin D3 1-alpha-Hydroxylase [D12.776.422.220.453.915.400]
        
        Steroid 12-alpha-Hydroxylase [D12.776.422.220.453.915.730]
        
        Steroid 16-alpha-Hydroxylase [D12.776.422.220.453.915.737]
        
        Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]
        
        Steroid 11-beta-Hydroxylase [D12.776.422.220.453.915.750]
        
        Steroid 21-Hydroxylase [D12.776.422.220.453.915.760]
        
        Sterol 14-Demethylase [D12.776.422.220.453.915.880]

Sterol 14-Demethylase Preferred

Concept UI: M0545190
Registry Number: EC 1.14.14.154
Scope Note: An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Terms: Sterol 14-Demethylase Preferred Term
Term UI T768707
Date04/06/2010
LexicalTag NON
ThesaurusID NLM (2011); Sterol 14-alpha-Demethylase
Term UI T768708
Date04/06/2010
LexicalTag NON
ThesaurusID NLM (2011); Lanosterol 14 alpha-Demethylase
Term UI T768709
Date04/06/2010
LexicalTag NON
ThesaurusID NLM (2011); CYP51 Cytochrome P-450
Term UI T768714
Date04/06/2010
LexicalTag ABX
ThesaurusID NLM (2011); Eburicol 14alpha-Demethylase
Term UI T768711
Date04/06/2010
LexicalTag NON
ThesaurusID NLM (2011); Obtusifoliol 14alpha-Demethylase
Term UI T768712
Date04/06/2010
LexicalTag NON
ThesaurusID NLM (2011); Cytochrome P-450 CYP51
Term UI T768713
Date04/06/2010
LexicalTag ABX
ThesaurusID NLM (2011); Sterol 14-Demethylases
Term UI T768695
Date04/05/2010
LexicalTag NON
ThesaurusID NLM (2011); Eburicol 14 alpha-Demethylase
Term UI T768710
Date04/06/2010
LexicalTag NON
ThesaurusID NLM (2011)

Sterol 14-Demethylase MeSH Descriptor Data 2024