MeSH Browser

MeSH Heading: Silver-Russell Syndrome
Tree Number(s): C05.660.207.925; C16.131.077.855; C16.131.260.870; C16.320.180.870; C16.320.240.937; C16.320.447.750
Unique ID: D056730
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056730
Scope Note: Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.
Entry Term(s): Russell Silver Syndrome; Russell-Silver Syndrome; Silver Russell Dwarfism; Silver-Russell Dwarfism
Previous Indexing: Growth Disorders (1970-2009)
See Also: Beckwith-Wiedemann Syndrome
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2023/04/14

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0528886
Scope Note: Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.
Terms: Silver-Russell Syndrome Preferred Term
Term UI T733979
Date01/27/2009
LexicalTag EPO
ThesaurusID; Silver-Russell Dwarfism
Term UI T733980
Date01/27/2009
LexicalTag EPO
ThesaurusID; Russell Silver Syndrome
Term UI T769779
Date04/19/2010
LexicalTag EPO
ThesaurusID; Russell-Silver Syndrome
Term UI T812070
Date11/15/2011
LexicalTag NON
ThesaurusID; Silver Russell Dwarfism
Term UI T734572
Date02/05/2009
LexicalTag EPO
ThesaurusID

Silver-Russell Syndrome MeSH Descriptor Data 2024