MeSH Browser

MeSH Heading: Costello Syndrome
Tree Number(s): C05.660.207.219; C16.131.077.256; C16.320.188
Unique ID: D056685
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056685
Scope Note: Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).
Entry Term(s): FCS Syndrome; Faciocutaneoskeletal Syndrome
See Also: Genes, ras; Noonan Syndrome; Proto-Oncogene Proteins p21(ras)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2019/07/01

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0528444
Scope Note: Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).
Terms: Costello Syndrome Preferred Term
Term UI T733187
Date01/13/2009
LexicalTag EPO
ThesaurusID; FCS Syndrome
Term UI T843516
Date05/02/2013
LexicalTag ABX
ThesaurusID GHR (2014); Faciocutaneoskeletal Syndrome
Term UI T733188
Date01/13/2009
LexicalTag NON
ThesaurusID

Costello Syndrome MeSH Descriptor Data 2024