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A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Entry Term(s)
Calcineurin A
Calcineurin B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B
Registry Numbers
EC 3.1.3.16
0
Previous Indexing
Calcium-Binding Proteins (1986-1997)
Calmodulin-Binding Proteins (1986-1997)
Phosphoprotein Phosphatase (1988-1997)
Public MeSH Note
98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.