Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Caspase 8 MeSH Descriptor Data 2025


MeSH Heading
Caspase 8
Tree Number(s)
D08.811.277.656.262.500.126.550.800
D08.811.277.656.300.200.126.550.800
D12.776.157.057.018.037
D12.776.476.024.320.025
D12.776.476.075.405.550.800
D12.776.476.075.421.037
Unique ID
D053181
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053181
Scope Note
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Entry Term(s)
CAP4 Protease
Caspase-8
FLICE Protein
MACH Protein
Mch5 Protease
Pro-Caspase-8
Procaspase-8
Registry Numbers
EC 3.4.22.-
0
See Also
Autoimmune Lymphoproliferative Syndrome
Public MeSH Note
2007; CASPASE 8 was indexed under CASPASES 1999-2006 & under CYSTEINE PROTEINASES 1997-1998
History Note
2007(2000)
Entry Combination
antagonists & inhibitors:Caspase Inhibitors
deficiency:Alstrom Syndrome
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2021/06/28
Caspase 8 Preferred
Procaspase-8 Narrower
page delivered in 0.135s