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NADPH Oxidases MeSH Descriptor Data 2025


MeSH Heading
NADPH Oxidases
Tree Number(s)
D08.811.682.608.575
D12.776.331.894
D12.776.543.653
Unique ID
D019255
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019255
Scope Note
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
Entry Term(s)
NAD(P)H Oxidases
NAD(P)H oxidase
NADPH Oxidase
Nox Proteins
Registry Numbers
EC 1.6.3.-
Previous Indexing
NADH, NADPH Oxidoreductases (1979-1996)
NADP (1972-1980)
Oxidoreductases (1972-1978)
See Also
Granulomatous Disease, Chronic
Public MeSH Note
2018; see NADPH OXIDASE 1997-2017; NAD(P)H OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 2000-2005; NADPH OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 1979-1996, NADP 1972-1980 & OXIDOREDUCTASES 1972-1978
History Note
2018 (1997)
Date Established
1997/01/01
Date of Entry
1996/06/10
Revision Date
2018/06/12
NADPH Oxidases Preferred
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