Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Dishevelled Proteins MeSH Descriptor Data 2025


MeSH Heading
Dishevelled Proteins
Tree Number(s)
D12.644.360.024.288
D12.776.157.057.028
D12.776.476.024.330
Unique ID
D000072261
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072261
Scope Note
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
Entry Term(s)
Dishevelled Protein
Dishevelled-1 Protein
Dishevelled-2 Protein
Dishevelled-3 Protein
Registry Numbers
0
Public MeSH Note
2017; DISHEVELLED PROTEINS was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2006-2016; under PHOSPHOPROTEINS 1998-2016; and under PROTEINS 1994-1997
History Note
2017 (1994)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2017/05/24
Dishevelled Proteins Preferred
Dishevelled-1 Protein Narrower
Dishevelled-2 Protein Narrower
Dishevelled-3 Protein Narrower
page delivered in 0.15s