MeSH Browser

MeSH Heading: GRB2 Adaptor Protein
Tree Number(s): D12.644.360.024.290; D12.776.157.057.041; D12.776.476.024.377
Unique ID: D051380
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051380
Scope Note: A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
Entry Term(s): Abundant Src Homology Protein; GRB2 Adaptor Protein, Grb3-3 Isoform; Grb3-3 Adaptor Protein; Growth Factor Receptor-Bound Protein-2
Registry Number: 0
Public MeSH Note: 2006; GROWTH FACTOR RECEPTOR-BOUND PROTEIN-2 was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2005, & under PROTEINS 1992-2004
History Note: 2006(1992)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2017/05/24

GRB2 Adaptor Protein MeSH Descriptor Data 2024