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A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
Entry Term(s)
Notch Protein
Notch Proteins
Notch Receptor
Notch Receptors
Registry Numbers
0
Public MeSH Note
2006; RECEPTORS, NOTCH was indexed under MEMBRANE PROTEINS 1990-2005, & under INSECT HORMONES 1990-1995
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.