MeSH Browser

MeSH Heading: Proliferating Cell Nuclear Antigen
Tree Number(s): D12.776.660.740; D23.050.290.750; D23.101.140.600
Unique ID: D018809
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018809
Scope Note: Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Entry Term(s): Antigen, Proliferating Cell Nuclear; PCNA
Registry Numbers: 0
Previous Indexing: Nuclear Proteins (1988-1994); Nucleoproteins (1983-1987)
Public MeSH Note: 95; PROLIFERATING CELL NUCLEAR ANTIGEN was indexed under NUCLEAR PROTEINS 1988-94 & NUCLEOPROTEINS 1983-87
Online Note: use PROLIFERATING CELL NUCLEAR ANTIGEN (NM) to search PROLIFERATING CELL NUCLEAR ANTIGEN 1983-94
History Note: 95; was PROLIFERATING CELL NUCLEAR ANTIGEN (NM) 1983-94
Date Established: 1995/01/01
Date of Entry: 1994/05/31
Revision Date: 2015/06/19

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0028162
Registry Numbers: 0
Scope Note: Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Terms: Proliferating Cell Nuclear Antigen Preferred Term
Term UI T056044
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1995); Antigen, Proliferating Cell Nuclear
Term UI T056043
Date04/29/1994
LexicalTag NON
ThesaurusID NLM (1995); PCNA
Term UI T056046
Date03/25/1994
LexicalTag ABB
ThesaurusID NLM (1995)

Proliferating Cell Nuclear Antigen MeSH Descriptor Data 2024