MeSH Browser

MeSH Heading: MAP Kinase Kinase Kinases
Tree Number(s): D08.811.913.696.620.682.700.559; D12.776.476.563.554
Unique ID: D020930
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020930
Scope Note: Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Entry Term(s): Kinases, MAP Kinase Kinase; MAP Kinase Kinase Kinase; MAP3 Kinase; MAP3 Kinases; MAPK-ERK Kinase Kinase; MAPK-ERK Kinase Kinases; MAPKKK; MAPKKKs; MEK Kinase; MEK Kinases; MEKK; MEKKs; Mitogen-Activated Protein Kinase Kinase Kinase; Mitogen-Activated Protein Kinase Kinase Kinases
Related Numbers: EC 2.7.11.25
Previous Indexing: Protein Kinases (1989-1999); Protein-Serine-Threonine Kinases (1993-1999); Protein-Tyrosine Kinase (1989-1999)
See Also: MAP Kinase Signaling System
Public MeSH Note: 2000; MAP KINASE KINASE KINASE (now MAP KINASE KINASE KINASES) was indexed under PROTEIN-SERINE-THREONINE KINASES 1992-1999
History Note: 2000; use MAP KINASE KINASE KINASE 1992-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2021/04/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Activin Receptors [D08.811.913.696.620.682.700.062]
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]
        
        Casein Kinases [D08.811.913.696.620.682.700.140]
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        Dyrk Kinases [D08.811.913.696.620.682.700.288]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        MAP Kinase Kinase Kinase 1 [D08.811.913.696.620.682.700.559.100]
        
        MAP Kinase Kinase Kinase 2 [D08.811.913.696.620.682.700.559.200]
        
        MAP Kinase Kinase Kinase 3 [D08.811.913.696.620.682.700.559.300]
        
        MAP Kinase Kinase Kinase 4 [D08.811.913.696.620.682.700.559.400]
        
        MAP Kinase Kinase Kinase 5 [D08.811.913.696.620.682.700.559.500]
        
        Mitogen-Activated Protein Kinase Kinase Kinase 11 [D08.811.913.696.620.682.700.559.650]
        
        Proto-Oncogene Proteins c-mos [D08.811.913.696.620.682.700.559.800]
        
        raf Kinases [D08.811.913.696.620.682.700.559.842]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NF-kappaB-Inducing Kinase [D08.811.913.696.620.682.700.579]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581]
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Polo-like Kinases [D08.811.913.696.620.682.700.616]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Protein Kinase C [D08.811.913.696.620.682.700.725]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]

MAP Kinase Kinase Kinases Preferred

Concept UI: M0328033
Related Numbers: EC 2.7.11.25
Scope Note: Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
Terms: MAP Kinase Kinase Kinases Preferred Term
Term UI T358033
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAP3 Kinase
Term UI T000997834
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); MAPKKK
Term UI T000997835
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Mitogen-Activated Protein Kinase Kinase Kinase
Term UI T000997836
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); MAP Kinase Kinase Kinase
Term UI T241156
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAPKKKs
Term UI T359206
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Kinases, MAP Kinase Kinase
Term UI T359207
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAP3 Kinases
Term UI T574035
Date02/24/2004
LexicalTag NON
ThesaurusID NLM (2005); Mitogen-Activated Protein Kinase Kinase Kinases
Term UI T574036
Date02/24/2004
LexicalTag NON
ThesaurusID NLM (2005)

MAPK-ERK Kinase Kinases Narrower

Concept UI: M0329022
Terms: MAPK-ERK Kinase Kinases Preferred Term
Term UI T359208
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAPK-ERK Kinase Kinase
Term UI T000997837
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); MEK Kinase
Term UI T000997838
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); MEKK
Term UI T000997839
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); MEKKs
Term UI T359209
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MEK Kinases
Term UI T359210
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

MAP Kinase Kinase Kinases MeSH Descriptor Data 2024