MeSH Browser

MeSH Heading: Sirtuins
Tree Number(s): D08.811.277.087.520.200.650; D08.811.913.400.725.115.961; D12.776.476.900
Unique ID: D037761
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D037761
Scope Note: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Entry Term(s): SIRT; SIRTs; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Proteins; Sirtuin
Previous Indexing: Histone Deacetylase (2000-2002)
See Also: Silent Information Regulator Proteins, Saccharomyces cerevisiae
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0413549
Scope Note: A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
Terms: Sirtuins Preferred Term
Term UI T480820
Date02/05/2002
LexicalTag ACX
ThesaurusID NLM (2003); SIRT
Term UI T000996386
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); Sirtuin
Term UI T000996263
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); SIRTs
Term UI T000941535
Date03/26/2018
LexicalTag ABB
ThesaurusID NLM (2019); Silent Mating Type Information Regulator 2-like Proteins
Term UI T480823
Date02/05/2002
LexicalTag NON
ThesaurusID NLM (2003); Sir2-like Proteins
Term UI T480821
Date02/05/2002
LexicalTag ACX
ThesaurusID NLM (2003)

Sirtuins MeSH Descriptor Data 2024