MeSH Browser

MeSH Heading: Apoptosis Inducing Factor
Tree Number(s): D08.811.682.608.047; D12.644.360.075.311; D12.776.157.687.063; D12.776.331.161; D12.776.476.075.311; D12.776.660.720.063
Unique ID: D051033
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051033
Annotation: INHIBITOR OF APOPTOSIS PROTEINS is also available
Scope Note: A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Entry Term(s): AIF Apoptosis Regulatory Protein; Apoptosis-Inducing Factor; Mitochondrial Apoptosis-Inducing Factor
Public MeSH Note: 2006; APOPTOSIS INDUCING FACTOR was indexed under FLAVOPROTEINS & MEMBRANE PROTEINS 1999-2005
History Note: 2006(1999)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0301106
Scope Note: A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Terms: Apoptosis Inducing Factor Preferred Term
Term UI T331111
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); AIF Apoptosis Regulatory Protein
Term UI T629104
Date01/28/2005
LexicalTag ABX
ThesaurusID NLM (2006); Apoptosis-Inducing Factor
Term UI T331109
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Mitochondrial Apoptosis-Inducing Factor
Term UI T331110
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

Apoptosis Inducing Factor MeSH Descriptor Data 2024