MeSH Browser

MeSH Heading: Mitogen-Activated Protein Kinase Kinases
Tree Number(s): D08.811.913.696.620.682.700.565; D08.811.913.696.620.682.725.200; D12.776.476.563.565; D12.776.476.568.200
Unique ID: D020929
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020929
Scope Note: A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Entry Term(s): MAP Kinase Kinases; MAP-ERK Kinase; MAPK Kinase; MAPK Kinases; MAPK-ERK Kinase; MAPK-ERK Kinases; MAPKK; MAPKKs; MEK; MEKs; Map Kinase Kinase; Mitogen-Activated Protein Kinase Kinase
Registry Numbers: EC 2.7.12.2; EC 2.7.12.2
Related Numbers: EC 2.7.12.2
Previous Indexing: Protein Kinases (1989-1999); Protein-Serine-Threonine Kinases (1993-1999); Protein-Tyrosine Kinase (1989-1999)
See Also: MAP Kinase Signaling System
Public MeSH Note: 2000; MAP KINASE KINASE and MAPKK (now MITOGEN-ACTIVATED KINASE KINASES) were indexed under PROTEIN KINASES 1992-1999; MAP-ERK KINASE (now MITOGEN-ACTIVATED KINASE KINASES) was indexed under PROTEIN-TYROSINE KINASE 1992-1999
History Note: 2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Activin Receptors [D08.811.913.696.620.682.700.062]
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]
        
        Casein Kinases [D08.811.913.696.620.682.700.140]
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        Dyrk Kinases [D08.811.913.696.620.682.700.288]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        MAP Kinase Kinase 1 [D08.811.913.696.620.682.700.565.100]
        
        MAP Kinase Kinase 2 [D08.811.913.696.620.682.700.565.200]
        
        MAP Kinase Kinase 3 [D08.811.913.696.620.682.700.565.300]
        
        MAP Kinase Kinase 4 [D08.811.913.696.620.682.700.565.400]
        
        MAP Kinase Kinase 5 [D08.811.913.696.620.682.700.565.500]
        
        MAP Kinase Kinase 6 [D08.811.913.696.620.682.700.565.600]
        
        MAP Kinase Kinase 7 [D08.811.913.696.620.682.700.565.700]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NF-kappaB-Inducing Kinase [D08.811.913.696.620.682.700.579]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581]
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Polo-like Kinases [D08.811.913.696.620.682.700.616]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Protein Kinase C [D08.811.913.696.620.682.700.725]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Agammaglobulinaemia Tyrosine Kinase [D08.811.913.696.620.682.725.025]
        
        Dyrk Kinases [D08.811.913.696.620.682.725.037]
        
        Focal Adhesion Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.049]
        
        Janus Kinases [D08.811.913.696.620.682.725.124]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
        
        MAP Kinase Kinase 1 [D08.811.913.696.620.682.725.200.100]
        
        MAP Kinase Kinase 2 [D08.811.913.696.620.682.725.200.200]
        
        MAP Kinase Kinase 3 [D08.811.913.696.620.682.725.200.300]
        
        MAP Kinase Kinase 4 [D08.811.913.696.620.682.725.200.400]
        
        MAP Kinase Kinase 5 [D08.811.913.696.620.682.725.200.500]
        
        MAP Kinase Kinase 6 [D08.811.913.696.620.682.725.200.600]
        
        MAP Kinase Kinase 7 [D08.811.913.696.620.682.725.200.700]
        
        Proto-Oncogene Proteins c-fes [D08.811.913.696.620.682.725.300]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Proto-Oncogene Proteins c-abl [D08.811.913.696.620.682.725.500]
        
        Syk Kinase [D08.811.913.696.620.682.725.650]
        
        src-Family Kinases [D08.811.913.696.620.682.725.800]
        
        ZAP-70 Protein-Tyrosine Kinase [D08.811.913.696.620.682.725.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]

Mitogen-Activated Protein Kinase Kinases Preferred

Concept UI: M0328038
Registry Numbers: EC 2.7.12.2
Related Numbers: EC 2.7.12.2
Scope Note: A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Terms: Mitogen-Activated Protein Kinase Kinases Preferred Term
Term UI T358038
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAPK Kinase
Term UI T000997315
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); Map Kinase Kinase
Term UI T232365
Date10/12/1999
LexicalTag ACX
ThesaurusID NLM (2000); MAPKK
Term UI T232366
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); MAP Kinase Kinases
Term UI T361670
Date10/12/1999
LexicalTag ACX
ThesaurusID NLM (2000); MAPK Kinases
Term UI T361671
Date10/12/1999
LexicalTag ACX
ThesaurusID NLM (2000); Mitogen-Activated Protein Kinase Kinase
Term UI T000997313
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); MAPKKs
Term UI T361672
Date10/12/1999
LexicalTag ACR
ThesaurusID NLM (2000)

MAPK-ERK Kinases Narrower

Concept UI: M0331456
Registry Numbers: EC 2.7.12.2
Terms: MAPK-ERK Kinases Preferred Term
Term UI T361673
Date10/12/1999
LexicalTag ACX
ThesaurusID NLM (2000); MAPK-ERK Kinase
Term UI T000997316
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); MEK
Term UI T001010881
Date03/25/2020
LexicalTag NON
ThesaurusID NLM (2021); MAP-ERK Kinase
Term UI T336704
Date10/12/1999
LexicalTag ACX
ThesaurusID NLM (2000); MEKs
Term UI T361674
Date10/12/1999
LexicalTag ACR
ThesaurusID NLM (2000)

Mitogen-Activated Protein Kinase Kinases MeSH Descriptor Data 2024