NLM Logo

Proto-Oncogene Proteins c-kit MeSH Descriptor Data 2022


MeSH Heading
Proto-Oncogene Proteins c-kit
Tree Number(s)
D08.811.913.696.620.682.725.400.050
D12.776.476.568.400.050
D12.776.543.750.630.124
D12.776.543.750.705.852.150.100
D12.776.543.750.750.400.200.170
D12.776.624.664.700.183
Unique ID
D019009
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019009
Scope Note
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Entry Term(s)
Antigens, CD117
CD117 Antigen
CD117 Antigens
Proto-Oncogene Protein c-kit
Proto-Oncogene Protein kit
Receptor, Stem Cell Factor
SCF Receptor
Stem Cell Factor Receptor
c-kit Protein
c-kit Receptor
kit Proto-Oncogene Protein
p145 c-kit
p145(c-kit)
p145c-kit
Registry Number
EC 2.7.10.1
Previous Indexing
Proto-Oncogene Proteins (1989-1995)
Receptor Protein-Tyrosine Kinase (1994-1995)
Receptors, Colony-Stimulating Factor (1991-1995)
See Also
Piebaldism
Public MeSH Note
2000; see PROTO-ONCOGENE PROTEINS C-KIT 1999-1996; PROTO-ONCOGENE PROTEIN KIT (now PROTO-ONCOGENE PROTEIN C-KIT) was indexed under RECEPTOR PROTEIN-TYROSINE KINASE 1994-1995; RECEPTORS, COLONY-STIMULATING FACTOR 1991-1995; & PROTO-ONCOGENE PROTEINS 1989-1995
History Note
2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995
Date Established
1996/01/01
Date of Entry
1995/05/26
Revision Date
2021/05/21
Proto-Oncogene Proteins c-kit Preferred
page delivered in 0.186s