MeSH Browser

MeSH Heading: BRCA2 Protein
Tree Number(s): D12.776.313.249; D12.776.624.776.101; D12.776.660.105
Unique ID: D024682
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D024682
Scope Note: A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Entry Term(s): BRCA2 Gene Product; Breast Cancer 2 Gene Product; Breast Cancer 2 Protein; FANCD1 Protein; Fanconi Anemia Complementation Group D1 Protein; Fanconi Anemia Group D1 Complementing Protein; Fanconi Anemia Group D1 Protein
Previous Indexing: Neoplasm Proteins (1995-2001); Transcription Factors (1995-2001)
See Also: Hereditary Breast and Ovarian Cancer Syndrome
Public MeSH Note: 2002; BCRA2 PROTEIN was indexed under NEOPLASM PROTEINS & TRANSCRIPTION FACTORS 1995-2001
History Note: 2002; use BRCA2 PROTEIN (NM) 1995-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2011/06/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0242709
Scope Note: A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Terms: BRCA2 Protein Preferred Term
Term UI T272714
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); FANCD1 Protein
Term UI T637912
Date04/26/2005
LexicalTag ACX
ThesaurusID NLM (2006); Fanconi Anemia Complementation Group D1 Protein
Term UI T637909
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006); BRCA2 Gene Product
Term UI T272713
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2002); Breast Cancer 2 Gene Product
Term UI T431450
Date12/20/2000
LexicalTag NON
ThesaurusID NLM (2002); Fanconi Anemia Group D1 Complementing Protein
Term UI T637910
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006); Breast Cancer 2 Protein
Term UI T637913
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006); Fanconi Anemia Group D1 Protein
Term UI T637911
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006)

BRCA2 Protein MeSH Descriptor Data 2024